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Research Highlights

Hundreds of scientists working at Cold Spring Harbor Laboratory contribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

The discerning fruit fly: Linking brain-cell activity and behavior in smell recognition

6/18/2013

It takes as few as 25 brain cells for a fly to characterize and distinguish among odors. Read the story »

CSHL geneticists solve mystery of EEC Syndrome’s variable severity in children

6/14/2013

By identifying a protein that acts as a genetic modifier, scientists at Cold Spring Harbor Laboratory (CSHL) have solved a mystery. Read the story »

Human Argonaute proteins: To slice or not to slice?

6/6/2013

Human Argonautes (hAgo), are key proteins involved in a process known as RNA interference Read the story »

Mathematical technique de-clutters cancer-cell data, revealing tumor evolution, treatment leads

6/5/2013

New technique reduces the burden of interpretation by identifying “cores of recurrent events.” Read the story »

CSHL neuroscientists show ’jumping genes’ may contribute to aging-related brain defects

4/7/2013

Transposon abundance and activity in the fruit fly brain increases with age and correlates with neurological degeneration. Read the story »

A cancer-promoting protein is found to also suppress cell growth

3/7/2013

The oncogenic splicing-factor protein SRSF1 also promotes cellular senescence through a novel mechanism involving p53 stabilization. Read the story »

Plant scientists at CSHL demonstrate new means of boosting maize yields

2/3/2013

Scientists successfully demonstrated what it describes as a “simple hypothesis” for making significant increases in yields for the maize plant. Read the story »

CSHL neuroscientists pinpoint location of fear memory in amygdala

1/27/2013

Fear responses based on experience are encoded in a circuit in the central amygdala Read the story »

Cancer scientists determine mechanism of one of the most powerful tumor-suppressor proteins, Chd5

1/10/2013

CSHL Professor Alea Mills explains what's so important about the Chd5 tumor suppressor and what her team has discovered about it. Read the story »

Scientists solve birth and migration mysteries of cortex’s powerful inhibitors, ‘chandelier’ cells

11/21/2012

Scientists discover the birth timing, embryonic origin and early development of chandelier cells, a class of inhibitory brain cells. Read the story »

Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells

11/3/2012

Researchers find method to target the cancer cell's metabolic process to destroy it. Read the story »

Neuroscientists propose a revolutionary DNA-based approach to map wiring of the whole brain

10/22/2012

Research propose a new and potentially revolutionary way of obtaining a neuronal connectivity map of the whole mouse brain. Read the story »

Biologists characterize enzymatic identity of key player in generating genome-protecting piRNAs

10/11/2012

Scientists work to understand the earliest steps in a process that protects animal genomes from potentially dangerous genetic elements Read the story »

Scientists reverse Alzheimer’s-like memory loss in animal models by blocking EGFR signaling

9/24/2012

EGFR inhibitors used to fight cancer show surprising efficacy in fly, mouse models of beta amyloid-associated memory loss Read the story »

Research identifies protein that regulates key ‘fate’ decision in cortical progenitor cells

9/20/2012

DOCK7 expression determines if radial glial cells will proliferate or differentiate Read the story »

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